ParkinsonCanadaV1, France, Analysis, bibRecord, 000083

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.

Identifieur interne : 000083 ( France/Analysis ); précédent : 000082; suivant : 000084

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.

Auteurs : Adam L. Boxer [États-Unis] ; Anthony E. Lang [Canada] ; Murray Grossman [États-Unis] ; David S. Knopman [États-Unis] ; Bruce L. Miller [États-Unis] ; Lon S. Schneider [États-Unis] ; Rachelle S. Doody [États-Unis] ; Andrew Lees [Royaume-Uni] ; Lawrence I. Golbe [États-Unis] ; David R. Williams [Australie] ; Jean-Cristophe Corvol [France] ; Albert Ludolph [Allemagne] ; David Burn [Royaume-Uni] ; Stefan Lorenzl [Allemagne] ; Irene Litvan [États-Unis] ; Erik D. Roberson [États-Unis] ; Günter U. Höglinger [Allemagne] ; Mary Koestler [États-Unis] ; Clifford R. Jack [États-Unis] ; Viviana Van Deerlin [États-Unis] ; Christopher Randolph [États-Unis] ; Iryna V. Lobach [États-Unis] ; Hilary W. Heuer [États-Unis] ; Illana Gozes [Israël] ; Lesley Parker [Canada] ; Steve Whitaker [États-Unis] ; Joe Hirman [États-Unis] ; Alistair J. Stewart [Canada] ; Michael Gold [États-Unis] ; Bruce H. Morimoto [États-Unis]

Source :

The Lancet. Neurology [ 1474-4465 ] ; 2014.

RBID : pubmed:24873720

English descriptors

KwdEn :
- Aged, Double-Blind Method, Female, Humans, Male, Oligopeptides (adverse effects), Oligopeptides (therapeutic use), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (drug therapy), Treatment Outcome.
MESH :
- chemical , adverse effects : Oligopeptides.
- chemical , therapeutic use : Oligopeptides.
- diagnosis : Supranuclear Palsy, Progressive.
- drug therapy : Supranuclear Palsy, Progressive.
- Aged, Double-Blind Method, Female, Humans, Male, Treatment Outcome.

Abstract

In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP.

DOI: 10.1016/S1474-4422(14)70088-2
PubMed: 24873720

Affiliations:

Links to Exploration step

pubmed:24873720

Le document en format XML

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<author><name sortKey="Doody, Rachelle S" sort="Doody, Rachelle S" uniqKey="Doody R" first="Rachelle S" last="Doody">Rachelle S. Doody</name>
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<author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name>
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<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
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<author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name>
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<author><name sortKey="Corvol, Jean Cristophe" sort="Corvol, Jean Cristophe" uniqKey="Corvol J" first="Jean-Cristophe" last="Corvol">Jean-Cristophe Corvol</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Assistance Publique-Hôpitaux de Paris, INSERM, CIC1422 and UMRS1027, Sorbonne Universités, Université Pierre et Marie Curie, Paris, France; Department of Neurology, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea>
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<author><name sortKey="Ludolph, Albert" sort="Ludolph, Albert" uniqKey="Ludolph A" first="Albert" last="Ludolph">Albert Ludolph</name>
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<author><name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
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<author><name sortKey="Lorenzl, Stefan" sort="Lorenzl, Stefan" uniqKey="Lorenzl S" first="Stefan" last="Lorenzl">Stefan Lorenzl</name>
<affiliation wicri:level="3"><nlm:affiliation>Interdisciplinary Center for Palliative Medicine, Munich University Hospital-Klinikum Grosshadern, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Interdisciplinary Center for Palliative Medicine, Munich University Hospital-Klinikum Grosshadern, Munich</wicri:regionArea>
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<region type="district" nuts="2">District de Haute-Bavière</region>
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</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of California, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberson, Erik D" sort="Roberson, Erik D" uniqKey="Roberson E" first="Erik D" last="Roberson">Erik D. Roberson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Alabama, Birmingham, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Alabama, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Translational Neurodegeneration, Technical University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Neurodegeneration, Technical University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koestler, Mary" sort="Koestler, Mary" uniqKey="Koestler M" first="Mary" last="Koestler">Mary Koestler</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Viviana" sort="Van Deerlin, Viviana" uniqKey="Van Deerlin V" first="Viviana" last="Van Deerlin">Viviana Van Deerlin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Randolph, Christopher" sort="Randolph, Christopher" uniqKey="Randolph C" first="Christopher" last="Randolph">Christopher Randolph</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Loyola University School of Medicine, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Loyola University School of Medicine, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lobach, Iryna V" sort="Lobach, Iryna V" uniqKey="Lobach I" first="Iryna V" last="Lobach">Iryna V. Lobach</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heuer, Hilary W" sort="Heuer, Hilary W" uniqKey="Heuer H" first="Hilary W" last="Heuer">Hilary W. Heuer</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gozes, Illana" sort="Gozes, Illana" uniqKey="Gozes I" first="Illana" last="Gozes">Illana Gozes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parker, Lesley" sort="Parker, Lesley" uniqKey="Parker L" first="Lesley" last="Parker">Lesley Parker</name>
<affiliation wicri:level="1"><nlm:affiliation>Tekmira Pharmaceuticals, Burnaby, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tekmira Pharmaceuticals, Burnaby, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whitaker, Steve" sort="Whitaker, Steve" uniqKey="Whitaker S" first="Steve" last="Whitaker">Steve Whitaker</name>
<affiliation wicri:level="2"><nlm:affiliation>Omeros, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Omeros, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirman, Joe" sort="Hirman, Joe" uniqKey="Hirman J" first="Joe" last="Hirman">Joe Hirman</name>
<affiliation wicri:level="2"><nlm:affiliation>Pacific Northwest Statistical Consulting, Woodinville, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Northwest Statistical Consulting, Woodinville, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stewart, Alistair J" sort="Stewart, Alistair J" uniqKey="Stewart A" first="Alistair J" last="Stewart">Alistair J. Stewart</name>
<affiliation wicri:level="1"><nlm:affiliation>Paladin Laboratories, St Laurent, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Paladin Laboratories, St Laurent, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gold, Michael" sort="Gold, Michael" uniqKey="Gold M" first="Michael" last="Gold">Michael Gold</name>
<affiliation wicri:level="2"><nlm:affiliation>UCB BioSciences, Research Triangle Park, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UCB BioSciences, Research Triangle Park, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morimoto, Bruce H" sort="Morimoto, Bruce H" uniqKey="Morimoto B" first="Bruce H" last="Morimoto">Bruce H. Morimoto</name>
<affiliation wicri:level="2"><nlm:affiliation>Celerion, Lincoln, NE, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celerion, Lincoln, NE</wicri:regionArea>
<placeName><region type="state">Nebraska</region>
</placeName>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.</title>
<author><name sortKey="Boxer, Adam L" sort="Boxer, Adam L" uniqKey="Boxer A" first="Adam L" last="Boxer">Adam L. Boxer</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address: aboxer@memory.ucsf.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Neurology, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schneider, Lon S" sort="Schneider, Lon S" uniqKey="Schneider L" first="Lon S" last="Schneider">Lon S. Schneider</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and the Behavioural Sciences and Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and the Behavioural Sciences and Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Doody, Rachelle S" sort="Doody, Rachelle S" uniqKey="Doody R" first="Rachelle S" last="Doody">Rachelle S. Doody</name>
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<author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ</wicri:regionArea>
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<author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name>
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<wicri:regionArea>Department of Neurology, University Hospital, Ulm</wicri:regionArea>
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<wicri:noRegion>Newcastle</wicri:noRegion>
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</author>
<author><name sortKey="Lorenzl, Stefan" sort="Lorenzl, Stefan" uniqKey="Lorenzl S" first="Stefan" last="Lorenzl">Stefan Lorenzl</name>
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<wicri:regionArea>Interdisciplinary Center for Palliative Medicine, Munich University Hospital-Klinikum Grosshadern, Munich</wicri:regionArea>
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<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberson, Erik D" sort="Roberson, Erik D" uniqKey="Roberson E" first="Erik D" last="Roberson">Erik D. Roberson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Alabama, Birmingham, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Alabama, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Translational Neurodegeneration, Technical University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Neurodegeneration, Technical University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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<author><name sortKey="Koestler, Mary" sort="Koestler, Mary" uniqKey="Koestler M" first="Mary" last="Koestler">Mary Koestler</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
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<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Viviana" sort="Van Deerlin, Viviana" uniqKey="Van Deerlin V" first="Viviana" last="Van Deerlin">Viviana Van Deerlin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Randolph, Christopher" sort="Randolph, Christopher" uniqKey="Randolph C" first="Christopher" last="Randolph">Christopher Randolph</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Loyola University School of Medicine, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Loyola University School of Medicine, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lobach, Iryna V" sort="Lobach, Iryna V" uniqKey="Lobach I" first="Iryna V" last="Lobach">Iryna V. Lobach</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heuer, Hilary W" sort="Heuer, Hilary W" uniqKey="Heuer H" first="Hilary W" last="Heuer">Hilary W. Heuer</name>
<affiliation wicri:level="2"><nlm:affiliation>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gozes, Illana" sort="Gozes, Illana" uniqKey="Gozes I" first="Illana" last="Gozes">Illana Gozes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parker, Lesley" sort="Parker, Lesley" uniqKey="Parker L" first="Lesley" last="Parker">Lesley Parker</name>
<affiliation wicri:level="1"><nlm:affiliation>Tekmira Pharmaceuticals, Burnaby, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tekmira Pharmaceuticals, Burnaby, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whitaker, Steve" sort="Whitaker, Steve" uniqKey="Whitaker S" first="Steve" last="Whitaker">Steve Whitaker</name>
<affiliation wicri:level="2"><nlm:affiliation>Omeros, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Omeros, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirman, Joe" sort="Hirman, Joe" uniqKey="Hirman J" first="Joe" last="Hirman">Joe Hirman</name>
<affiliation wicri:level="2"><nlm:affiliation>Pacific Northwest Statistical Consulting, Woodinville, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pacific Northwest Statistical Consulting, Woodinville, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stewart, Alistair J" sort="Stewart, Alistair J" uniqKey="Stewart A" first="Alistair J" last="Stewart">Alistair J. Stewart</name>
<affiliation wicri:level="1"><nlm:affiliation>Paladin Laboratories, St Laurent, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Paladin Laboratories, St Laurent, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gold, Michael" sort="Gold, Michael" uniqKey="Gold M" first="Michael" last="Gold">Michael Gold</name>
<affiliation wicri:level="2"><nlm:affiliation>UCB BioSciences, Research Triangle Park, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UCB BioSciences, Research Triangle Park, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morimoto, Bruce H" sort="Morimoto, Bruce H" uniqKey="Morimoto B" first="Bruce H" last="Morimoto">Bruce H. Morimoto</name>
<affiliation wicri:level="2"><nlm:affiliation>Celerion, Lincoln, NE, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celerion, Lincoln, NE</wicri:regionArea>
<placeName><region type="state">Nebraska</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Neurology</title>
<idno type="eISSN">1474-4465</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Oligopeptides (adverse effects)</term>
<term>Oligopeptides (therapeutic use)</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Oligopeptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Oligopeptides</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
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<li>États-Unis</li>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="Boxer, Adam L" sort="Boxer, Adam L" uniqKey="Boxer A" first="Adam L" last="Boxer">Adam L. Boxer</name>
</region>
<name sortKey="Doody, Rachelle S" sort="Doody, Rachelle S" uniqKey="Doody R" first="Rachelle S" last="Doody">Rachelle S. Doody</name>
<name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
<name sortKey="Gold, Michael" sort="Gold, Michael" uniqKey="Gold M" first="Michael" last="Gold">Michael Gold</name>
<name sortKey="Grossman, Murray" sort="Grossman, Murray" uniqKey="Grossman M" first="Murray" last="Grossman">Murray Grossman</name>
<name sortKey="Heuer, Hilary W" sort="Heuer, Hilary W" uniqKey="Heuer H" first="Hilary W" last="Heuer">Hilary W. Heuer</name>
<name sortKey="Hirman, Joe" sort="Hirman, Joe" uniqKey="Hirman J" first="Joe" last="Hirman">Joe Hirman</name>
<name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<name sortKey="Koestler, Mary" sort="Koestler, Mary" uniqKey="Koestler M" first="Mary" last="Koestler">Mary Koestler</name>
<name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<name sortKey="Lobach, Iryna V" sort="Lobach, Iryna V" uniqKey="Lobach I" first="Iryna V" last="Lobach">Iryna V. Lobach</name>
<name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<name sortKey="Morimoto, Bruce H" sort="Morimoto, Bruce H" uniqKey="Morimoto B" first="Bruce H" last="Morimoto">Bruce H. Morimoto</name>
<name sortKey="Randolph, Christopher" sort="Randolph, Christopher" uniqKey="Randolph C" first="Christopher" last="Randolph">Christopher Randolph</name>
<name sortKey="Roberson, Erik D" sort="Roberson, Erik D" uniqKey="Roberson E" first="Erik D" last="Roberson">Erik D. Roberson</name>
<name sortKey="Schneider, Lon S" sort="Schneider, Lon S" uniqKey="Schneider L" first="Lon S" last="Schneider">Lon S. Schneider</name>
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<name sortKey="Whitaker, Steve" sort="Whitaker, Steve" uniqKey="Whitaker S" first="Steve" last="Whitaker">Steve Whitaker</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
</region>
<name sortKey="Parker, Lesley" sort="Parker, Lesley" uniqKey="Parker L" first="Lesley" last="Parker">Lesley Parker</name>
<name sortKey="Stewart, Alistair J" sort="Stewart, Alistair J" uniqKey="Stewart A" first="Alistair J" last="Stewart">Alistair J. Stewart</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name>
</region>
<name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
</country>
<country name="Australie"><noRegion><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name>
</noRegion>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Corvol, Jean Cristophe" sort="Corvol, Jean Cristophe" uniqKey="Corvol J" first="Jean-Cristophe" last="Corvol">Jean-Cristophe Corvol</name>
</region>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ludolph, Albert" sort="Ludolph, Albert" uniqKey="Ludolph A" first="Albert" last="Ludolph">Albert Ludolph</name>
</region>
<name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name>
<name sortKey="Lorenzl, Stefan" sort="Lorenzl, Stefan" uniqKey="Lorenzl S" first="Stefan" last="Lorenzl">Stefan Lorenzl</name>
</country>
<country name="Israël"><noRegion><name sortKey="Gozes, Illana" sort="Gozes, Illana" uniqKey="Gozes I" first="Illana" last="Gozes">Illana Gozes</name>
</noRegion>
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</tree>
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</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.

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	La maladie de Parkinson au Canada (serveur d'exploration)
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